Primary hypothyroidism with paradoxically elevated plasma thyroxine due to thyroxine-binding antibody.
نویسندگان
چکیده
منابع مشابه
Low serum thyroxine due to anti-thyroxine antibody.
In one case of untreated Hashimoto's thyroiditis, the serum thyroxine (T4) value, obtained by radioimmunoassay (RIA) employing resin to separate bound and free T4, was significantly lower than that obtained by competitive protein binding analysis (CPBA). The discrepancy was found to be due to the presence of anti-thyroxine autoantibody in the serum. This phenomenon is considered to be of practi...
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The optimum daily dose of thyroxine was calculated for 13 children aged 3-16 years with primary hypothyroidism by titrating their doses at monthly intervals. The condition of the thyroid was assessed by sensitive assay of thyroid stimulating hormone concentrations, as well as measurement of total and free thyroid hormone concentrations and systolic time interval ratios. Serum thyroid stimulatin...
متن کاملThyroxine-binding prealbumin in thyrotoxicosis and hypothyroidism.
THYROXINE is reversibly bound in the plasma to three proteins: thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin. Changes in the binding capacities of TBG and TBPA in patients with thyroid disease have been reported previously (1, 2). Since starch-gel electrophoresis of serums of patients with thyrotoxicosis indicated a marked decrease in density of the stain in...
متن کاملUnforeseen effect of thyroxine binding globulin when using the microencapsulated antibody method to determine free thyroxine (FT4): misleading results due to circulating unsaturated thyroxine binding globulin.
The effect of varying concentrations (0-52 mg/l) of purified thyroxine binding globulin (TBG) on the microencapsulated antibody method for free thyroxine was investigated. The results demonstrated that the free thyroxine values were strongly influenced by the concentration of thyroxine binding globulin in the samples. The standard curve could no longer be distinguished at a concentration of pur...
متن کاملCongenital hypothyroidism with hereditary, raised thyroxine binding globulin.
A boy with congenital hypothyroidism and hereditary raised thyroxine binding globulin is described. This hitherto unreported combination resulted in under treatment of the thyroid deficiency until serum thyroid stimulating hormone measurement became routinely available. Inadequate L-thyroxine replacement treatment between 2 and 7 years of age caused retarded bone maturation, poor growth velocit...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1986
ISSN: 0032-5473
DOI: 10.1136/pgmj.62.731.845